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Early-life and pubertal stress differentially modulate grey matter development in human adolescents

Show simple item record Tyborowska, Anna Volman, Inge Niermann, Hannah Pouwels, Loes Smeekens, Sanny Cillessen, Antonius Toni, Ivan Roelofs, Karins 2018-11-29T21:56:31Z 2018-11-29T21:56:31Z 2018
dc.identifier.citation Tyborowska, Anna; Volman, Inge; Niermann, Hannah; Pouwels, Loes; Smeekens, Sanny; Cillessen, Antonius; Toni, Ivan; Roelofs, Karin (2018). Early-life and pubertal stress differentially modulate grey matter development in human adolescents. Nature Scientific Reports: 8 (No. 9201), 11 pgs. en_US
dc.description.abstract Animal and human studies have shown that both early-life traumatic events and ongoing stress episodes affect neurodevelopment, however, it remains unclear whether and how they modulate normative adolescent neuro-maturational trajectories. We characterized effects of early-life (age 0–5) and ongoing stressors (age 14–17) on longitudinal changes (age 14 to17) in grey matter volume (GMV) of healthy adolescents (n = 37). Timing and stressor type were related to differential GMV changes. More personal early-life stressful events were associated with larger developmental reductions in GMV over anterior prefrontal cortex, amygdala and other subcortical regions; whereas ongoing stress from the adolescents’ social environment was related to smaller reductions over the orbitofrontal and anterior cingulate cortex. These findings suggest that early-life stress accelerates pubertal development, whereas an adverse adolescent social environment disturbs brain maturation with potential mental health implications: delayed anterior cingulate maturation was associated with more antisocial traits – a juvenile precursor of psychopathy. (Author Abstract) en_US
dc.language.iso en_US en_US
dc.publisher Nature en_US
dc.subject Research en_US
dc.subject Brain en_US
dc.subject Neuroimaging en_US
dc.subject Neuroscience en_US
dc.subject Neurobiology of Trauma en_US
dc.subject Stress Response en_US
dc.subject Posttraumatic Stress en_US
dc.subject Emotional Distress en_US
dc.subject Adolescence en_US
dc.subject Anti-social Behavior en_US
dc.subject Behavioral Problems en_US
dc.subject Behavioral Health en_US
dc.subject Trauma en_US
dc.subject Child Abuse en_US
dc.subject Psychological Consequences en_US
dc.subject Psychogical Burdens en_US
dc.subject Teens en_US
dc.subject Youth en_US
dc.subject Long Term Effects en_US
dc.subject Adverse Childhood Experiences en_US
dc.subject Mental Health en_US
dc.subject International en_US
dc.subject Netherlands en_US
dc.title Early-life and pubertal stress differentially modulate grey matter development in human adolescents en_US
dc.type Article en_US

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