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Early-life and pubertal stress differentially modulate grey matter development in human adolescents

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dc.contributor.author Tyborowska, Anna
dc.contributor.author Volman, Inge
dc.contributor.author Niermann, Hannah
dc.contributor.author Pouwels, Loes
dc.contributor.author Smeekens, Sanny
dc.contributor.author Cillessen, Antonius
dc.contributor.author Toni, Ivan
dc.contributor.author Roelofs, Karins
dc.date.accessioned 2018-11-29T21:56:31Z
dc.date.available 2018-11-29T21:56:31Z
dc.date.issued 2018
dc.identifier.citation Tyborowska, Anna; Volman, Inge; Niermann, Hannah; Pouwels, Loes; Smeekens, Sanny; Cillessen, Antonius; Toni, Ivan; Roelofs, Karin (2018). Early-life and pubertal stress differentially modulate grey matter development in human adolescents. Nature Scientific Reports: 8 (No. 9201), 11 pgs. en_US
dc.identifier.uri https://www.nature.com/articles/s41598-018-27439-5
dc.identifier.uri http://hdl.handle.net/20.500.11990/992
dc.description.abstract Animal and human studies have shown that both early-life traumatic events and ongoing stress episodes affect neurodevelopment, however, it remains unclear whether and how they modulate normative adolescent neuro-maturational trajectories. We characterized effects of early-life (age 0–5) and ongoing stressors (age 14–17) on longitudinal changes (age 14 to17) in grey matter volume (GMV) of healthy adolescents (n = 37). Timing and stressor type were related to differential GMV changes. More personal early-life stressful events were associated with larger developmental reductions in GMV over anterior prefrontal cortex, amygdala and other subcortical regions; whereas ongoing stress from the adolescents’ social environment was related to smaller reductions over the orbitofrontal and anterior cingulate cortex. These findings suggest that early-life stress accelerates pubertal development, whereas an adverse adolescent social environment disturbs brain maturation with potential mental health implications: delayed anterior cingulate maturation was associated with more antisocial traits – a juvenile precursor of psychopathy. (Author Abstract) en_US
dc.language.iso en_US en_US
dc.publisher Nature en_US
dc.subject Research en_US
dc.subject Brain en_US
dc.subject Neuroimaging en_US
dc.subject Neuroscience en_US
dc.subject Neurobiology of Trauma en_US
dc.subject Stress Response en_US
dc.subject Posttraumatic Stress en_US
dc.subject Emotional Distress en_US
dc.subject Adolescence en_US
dc.subject Anti-social Behavior en_US
dc.subject Behavioral Problems en_US
dc.subject Behavioral Health en_US
dc.subject Trauma en_US
dc.subject Child Abuse en_US
dc.subject Psychological Consequences en_US
dc.subject Psychogical Burdens en_US
dc.subject Teens en_US
dc.subject Youth en_US
dc.subject Long Term Effects en_US
dc.subject Adverse Childhood Experiences en_US
dc.subject Mental Health en_US
dc.subject International en_US
dc.subject Netherlands en_US
dc.title Early-life and pubertal stress differentially modulate grey matter development in human adolescents en_US
dc.type Article en_US


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